Arginine vasopressin receptor signaling and functional outcomes in heart failure
نویسندگان
چکیده
منابع مشابه
Arginine Vasopressin Receptor Antagonists for Heart Failure
eart failure (HF) is among the most common causes of ospitalization, and its incidence will likely increase in an ging population of “survivors” (1). Pharmacological treatent targeted at neurohormonal activation has improved urvival, but mortality remains substantial in patients with F, thus warranting the search for novel therapeutic aproaches. Novel agents under investigation for the treatent...
متن کاملArginine vasopressin in heart failure.
Pathogenesis of AVP Release In several animal models of low-output and high-output cardiac failure and in congestive heart failure in humans, it has been demonstrated that plasma AVP, renin activity, aldosterone and norepinephrine are significantly increased.7 Renal excretion of sodium and water is predominantly regulated by the integrity of the arterial circulation, which is determined by card...
متن کاملVasopressin receptor antagonists in heart failure.
Vasopressin receptor antagonists are a new class of drugs that address the problems of fluid retention, hyponatremia, and renal dysfunction in heart failure. Elevated vasopressin levels in heart failure cause myocardial fibrosis, hypertrophy and vasoconstriction by activating the V1a receptors, as well as water retention and hyponatremia by activating V2 receptors. Antagonism of V1a receptors a...
متن کاملFunctional arginine vasopressin system in early heart maturation.
Since the neurohypophyseal hormone 8-arginine vasopressin (AVP) is involved in cardiovascular tissue hypertrophy and myocyte differentiation, it is possible that local AVP plays a role in heart maturation. AVP-specific RIA, RT-PCR, and immunoblot measurement of AVP receptors (VR) were used to investigate heart tissues from newborn and adult rats. To test AVP's role in differentiation and specia...
متن کاملAssessment of obestatin and arginine vasopressin (AVP) levels in acute renal failure and acute heart failure.
OBJECTIVE We conducted this study to assess the clinical application of obestatin and arginine vasopressin (AVP) levels in cases of acute renal failure (ARF) and acute heart failure (AHF). PATIENTS AND METHODS 30 cases of ARF, 30 cases of AHF, 30 cases of ARF complicated with AHF, and 30 cases of healthy subjects (control group) were successively selected. An ELISA test was conducted to detec...
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ژورنال
عنوان ژورنال: Cellular Signalling
سال: 2016
ISSN: 0898-6568
DOI: 10.1016/j.cellsig.2015.07.021